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                    [Faculty of Islamic Studies and Social Science][Faculty of Pharmacy][Faculty of Management Studies and Information Technology] [Faculty of Nursing] [Faculty of Medicine][Faculty of Science]                

 

ADMISSION &

EXAMINATION RULES

&

SYLLABUS

FOR

Diploma in Pharmacy 

 

 SYLLABI   

 DIPLOMA  FIRST  YEAR 

ADMISSION & EXAMINATION RULES
FOR
DIPLOMA IN PHARMACY

(Approved by the Standing Committee of the Academic Council in March 1997 to be effective from the Academic Session 1997-98 and applicable to all D. Pharm students) 

1.          Programme :  Diploma in Pharmacy (D. Pharm.) 

It shall be a full time regular course.

 

During an academic year, a candidate shall be enrolled only for one programme of study and shall not appear in any other examination of this or any other university. 

2.      Duration :        Two years 

3.      Medium of Instruction and Examination :         English 

4.         Eligibility for Admission :         A candidate seeking admission to this course must have:

 

(a)passed 10+2 examination from Central Board of Secondary Education or any other examination recognized by Jamia Hamdard as equivalent thereto, with at least 50% marks in the aggregate of Physics, Chemistry and Biology subjects, and must have passed in each of these subjects. 

(b)qualified the admission test / interview conducted by Jamia Hamdard. 

(c)Completed the age of 17 years on or before the first day of October of the year of admission. 

Some seats are provided for those candidates who opt for an additional course in Unani Pharmacy. All such candidates will have to take all the examinations in Modern Pharmacy in addition to the additional papers in Unani Pharmacy (Urdu medium). On the successful completion of the course, these candidates will be entitled to the award of degree in Modern Pharmacy and a separate certificate for Unani course. Proficiency in Urdu, comparable to Matric standard is essential for such candidates.

 5.Course Structure: 

The number of hours of teaching in theory as well as practical in the various subjects of Diploma in Pharmacy Part-I and Part-II are listed below. Each academic year will have at least 180 working days. There will be a total of 500 hours of practical training spread over a period of not less than 3 months. The course contents are given in the Syllabus.

 

S.No.

Subject

Paper

Number of

Hours per

Years

 

 

No

Theory

Practical

Total

1.

Part-I Pharmaceutics-I

I

75

100

175

2.

Pharmaceutical Chemistry-I

II

75

75

150

3.

Pharmacognosy

III

75

75

150

4.

Biochemistry & Clinical Pathology

IV

50

75

125

5.

Human Anatomy & Physiology

V

75

50

125

6.

Health Education & Community Pharmacy

IV

50

-

50

 

 

 

400

375

775

 

Unani Pharmacy

DU-I

25

-

25

1.

Part-II Pharmaceutics-II

VII

75

100

175

2.

Pharmaceutical Chemistry-II (Organic Chemistry)

VIII

100

75

175

3.

Pharmacology & Toxicology

IX

75

50

125

4.

Pharmaceutical Jurisprudence

X

50

-

50

5.

Drug Store & Business Management

XI

75

-

75

6.

Hospital & Clinical Pharmacy

XII

75

50

125

 

 

 

450

275

725

 

Unani Pharmacy

DU-II

15

10

25

 
6.      Scheme of Examination: 

The distribution of marks for theory and practical work in different papers during the course of study is detailed below. The duration of annual examination in theory as well as practical papers will be 3 hours.

 

YEAR / Paper

Marks in Theory

Total

Marks in Practical

Total

Grand Total

 

Annual

Sessional

 

Annual

Sessional

 

 

Part-I

 

 

 

 

 

 

 

Pharmaceutics-I

80

20

100

80

20

100

200

Pharmaceutical Chemistry-I

80

20

100

80

20

100

200

Pharmacognosy

80

20

100

80

20

100

200

Biochemistry & Clinical Pathology

80

20

100

80

20

100

200

Human Anatomy & Physiology

80

20

100

80

20

100

200

Total

 

 

600

 

 

500

1100

Unani Pharmacy

80

20

100

-

-

-

100

Part-II

 

 

 

 

 

 

 

Pharmaceutics-II

80

20

100

80

20

100

200

Pharmaceutical Chemistry-II (Organic Chemistry)

80

20

100

80

20

100

200

Pharmacology & Toxicology

80

20

100

80

20

100

200

Pharmaceutical Jurisprudence

80

20

100

80

20

100

200

Drug Store & Business Management

80

20

100

-

-

-

100

Hospital & Clinical Pharmacy

80

20

100

80

20

100

200

Total

 

 

600

 

 

400

1000

Unani Pharmacy

80

20

100

80

20

100

200

 

7.      Internal Assessment: 

A.For the purpose of awarding Sessional marks in theory paper, performance of student shall be evaluated on the basis of at least two written tests. These will be given by the respective teachers . The sessional marks in practicals shall be allotted on the following basis ,

         a. Actual performance in the sessional examination-         10 marks

         b. Day to day assessment in the practical class work -         10 marks

 

B.Each theory test will be of two hours duration. These will be conducted as per a schedule notified by the Dean, Faculty of Pharmacy. Practical sessional tests will be conducted in regular classes by respective teachers.

 

C.The marks obtained shall be notified in time by the respective teachers and answer books shown to the students, if they wish so. The sessional test answer books shall be retained in the department till the end of the academic term.

 

D.There shall be at least three tests for each course and the average of best two tests shall be taken to award the sessional marks. There will be no provision for special or additional internal assessment tests.

 

E.A regular record of the marks for sessional test conducted in an academic year shall be maintained by the teacher concerned/Head of Department for each student.

 

F.The final sessional marks shall be submitted by the teachers to the Head of the Department who shall forward the same to the Registrar, within ten days of the last sessional test held. These marks shall also be displayed on the Notice Board of the Department/Faculty.

 

8.Attendance: 

A.All students must attend every lecture and practical class. However, to account for late joining or other such contingencies, the attendance requirement for appearing in the examination shall be a minimum of 75% of the classes actually held. 

B.In order to maintain the attendance record of a particular course, a roll call will be taken by the teacher in every scheduled lecture and practical class. For the purpose of attendance, every scheduled practical class will be counted as one attendance unit, irrespective of the number of contact hours. 

C.The teacher in charge will consolidate the attendance record for the lectures and practicals for each term. Attendance on account of participation in the prescribed functions of NCC, NSS, Inter-university sports, educational tours/field work shall be credited to the aggregate, provided the attendance record, duly countersigned by the officer in charge, is sent to the Dean of Faculty within two weeks of the function/activity etc. 

D.The statements of attendance of students shall be displayed on the Department Notice Board at the close of each term as given in the University Calendar. A copy of the same shall be sent to the Head of Department/Office of Dean of Faculty for record Notice displayed on Notice Board shall be deemed to be a proper notification, and so individual notice shall be sent to students. 

E.If a student is found to be continuously absent from the classes without information for a period of 30 days, the teacher in-charge shall report it to the Head of Department/Dean for striking off the name of such a student from rolls. Such a student may, however, apply for readmission within 15 days from the date of issue of the notice of striking off the name. The request may be considered by the Dean for readmission. Such a student shall not be readmitted after the prescribed period. Their admission shall be effected on payment of prescribed readmission fees. 

F.A student with less than 75% attendance of the lectures and practicals separately in each subject/course in an academic year shall be detained from appearing in the Annual University examination. The Dean of Faculty concerned may consider application for the condonation of attendance upto 5% on account of sickness, provided the application for condonation of attendance, duly certified by a Registered Medical practitioner/Public Hospital had been submitted within 5 days from the recovery from illness. Condonation of attendance on account of any other extenuating circumstances may also be considered, provided the request is duly supported by documentary evidence. 

G.A student detained on account of attendance will be readmitted to the same class in the next academic year on payment of current fees except Enrolment fee, Identity card fee and Security deposits. 

9.Eligibility for admission to examination: 

A student seeking admission to the examination to be held at the end of each academic year must have pursued a regular course of study for one academic year and must have completed the prescribed attendance requirements. Further, a student admitted to any course must pass the first year examination within two academic years, and must complete the full course of study within the prescribed span period of four years. 

10.Annual and Supplementary examination: 

A.The Annual and Supplementary examinations shall be held as per schedule given in the Academic Calendar of Jamia Hamdard. The Supplementary examinations may normally be held after 30 days from the declaration of results of the Annual examinations. 

B.A candidate who fails to appear at the Annual examination or having appeared in the Annual examination fails to pass in any subject(s) as prescribed for the examination, may be allowed to appear in the remaining subjects at the Supplementary examination.

C.A candidate will be given a total number of three attempts, inclusive of the first attempt, to clear the papers in which he/she fails to qualify (irrespective of the number of such papers). In exceptionally hard cases, a student may be considered for grant of one last mercy chance. 

D.Application for mercy chance with proper justification and a written undertaking given by the student will be examined by the Dean of the Faculty, and specific recommendations will be forwarded to the Registrar for getting approval of the competent authority. The undertaking would be to the effect that in case he/she does not clear the backlog in this final attempt, he/she not have any further claim to continue the studies and that his/her name may be struck off the rolls.

 E.The duration of annual examination in theory as well as practical papers will be 3 hours. Unless specified otherwise.

 F.Examiners shall examine students orally during the Practical examinational and take cognizance of their performance when marking their papers.

 G.A student shall not be declared to have passed the examination unless he/she secures at least 40% marks in each of the subjects separately in the theory as well as practical examinations, including sessional marks. Each theory paper or practical examination shall be construed as a separate paper.

 H.Ten days vacation shall be given as preparatory holidays before the commencement of Annual examinations.

 I.The candidates will retain the Internal Assessment of the previous examination, wherever applicable. 

11.Promotion to next class: 

A.All candidates who have appeared for all the subjects and passed the Diploma in Pharmacy Part-I examination are eligible for promotion to the Diploma in Pharmacy Part-II class. However, failure in more than two subjects shall debar the candidate from promotion to Part-II 

B.After having appeared in Diploma in Pharmacy Part-II examination, a candidate shall be eligible to undergo a practical training as per the guidelines and rules prescribed by the Pharmacy Council of India in this regard.

 C.The certificate of Diploma in Pharmacy shall only be awarded after the completion of the Practical Training.

 12.Classification of successful candidates:

 A.The result of the successful candidates shall be classified at the end of the second year examination on the basis of the aggregate of all subjects, Theory and Practicals, secured by the candidate in the I and II year examinations, as indicated below:

 

                  Ist Division         :         60% and above

                  2nd Division         :         50%-59.9%

                  Pass         :         40%-49%

 

B.Candidates securing 75% or above marks in any subjects(s) and have passed in all the subjects in a year in first attempt shall be declared to have obtained Distinction in that subject(s). 

13.Span Period: 

A.Students admitted to Diploma in Pharmacy course must pass the first year examination within two years from their first admission to the course. 

B.Students must pass all the examinations required for the award of the Diploma within a maximum period of four years.

 

PHARMACEUTICS   1

Theory (75 hours)

1.      Introduction of different dosage forms. Their classification with example and their relative applications. Familiarization with new drug delivery systems.

2.      Introduction to Pharmacopoeias with special reference to the Indian Pharmacopoeia.

3.      Metrology-Systems of weights and measures. Calculations including conversion from one to another system, Percentage calculations and adjustment of products. Use of allegation method in calculations. Isotonic solutions.

4.      Packaging of Pharmaceuticals-Desirable features of a container-types of containers. Study of glass and plastics as materials for containers and rubber as a material for closures their merits and demerits. Introduction to aerosol packaging.

5.      Size reduction - Objectives, and factors affecting size reduction, methods of size reduction- Study of hammer mill, ball mill, fluid energy mill and disintegrator.

6.      Size separation - Size separation by sifting, Official standards for powders, Sedimentation methods of size separation, Construction and working of Cyclone separator.

7.      Mixing and Homogenization - Liquid mixing and powder mixing, Mixing of semisolids. Study of Silverson Mixer- Homogenizer, Planetary Mixer; Agitated powder mixer, Triple Roller Mill, Propeller Mixer, Colloid Mill and Hand Homogenizer, Double cone mixer.

8 .     Clarification and Filtration-Theory of filtration, Filter media, Filter aids and selection of filters. Study of the following filteration equipments-Filter Press, Sintered Filters. Filter Candles, Metafilter.

9.      Extraction and Galenicals         (a) Study of percolation and maceration and their modifications, continuous hot extraction. Applications in the preparation of tinctures and extracts. (b) Introduction to Ayurvedic dosage forms.

10.     Heat processes - Evaporation - Definition - Factors affecting evaporation - Study of evaporating still and Evaporating Pan.

11.     Distillation - Simple distillation and Fractional distillation, Steam distillation and vacuum distillation. Study of vacuum still, preparation of Purified Water I.P. and water for Injection I.P. Construction and working of the still used for the same.

12.     Introduction to drying processes - Study of Tray Dryers, Fluidized Bed Dryer, Vacuum Dryer and Freeze Dryer.

13.     Sterilization - Concept of sterilization and its differences from disinfection - Thermal resistance of microorganisms, Detailed study of the following sterilization processes.

i)      Sterilization with moist heat,        ii)     Dry heat sterilization,

iii)    Sterilization by radiation,           iv)     Sterilization filtration and              v) Gaseous sterilization.

Aseptic  techniques - Application of sterilization processes in hospitals particularly with reference to surgical dressings and intravenous fluids. Precautions for safe and effective handling of sterilization equipment.

14.     Processing of Tablets - Definition; Different types of compressed tablets and their properties. Processes involved in the production of tablets; Tablets excipients; Defects in tablets; Evaluation of Tablets; Physical standards including Disintegration and Dissolution. Tablet coating-Sugar coating-,film coating, enteric coating and microencapsulation (Tablet coating may begin an elementary manner).

15.     Processing of Capsules Hard and soft gelatin capsules;  different sizes of capsules; filling of capsules; handling and storage of capsules. Special applications of capsules.

16.Study of immunological products like sera, vaccines, toxoids & their preparations. PRACTICAL

(100 hours)

Preparation (minimum number stated against each) of the following categories illustrating

different techniques involved.

1.      Automatic waters            3.                     7 .     Cosmetic preparation-               3

2.      Solutions                        4.                     8.      Capsules                                    2

3.      Spirits                             2                      9.      Tablets                                        2

4.      Tinctures                        4                      10.     Preparations involving sterilization - 2

5 .     Extracts                         2                                  11.     Ophthalmic preparations -           2

6 .     Creams                          2                      12.     Preparations involving asceptic techniques      2

 Books Recommended: (Latest editions)

1.      Remington's Pharmaceutical Sciences.             2.      The Extra Pharmacopoeia-Martindale.

 PHARMACEUTICAL CHEMISTRY-1

Theory (75 hours)

General discussion on the following inorganic compounds including important physical and chemical properties, medicinal and pharmaceutical uses, storage conditions and chemical incompatibility.

a. Acids, bases and buffers - Boric acid*, Hydrochloric acid, strong ammonium hydroxide, Calcium hydroxide, Sodium hydroxide and official buffers.

b. Antioxidants - Hypophosphorous acid, dioxide, Sodium bisulphite, Sodium meta-bisulphite., Sodium thiosulphate, Nitrogen and Sodium Nitrite.

c. Gastrointestinal agents

i)        Acidifying agents - Dilute hydrochloric acid

ii)       Antacids - Sodium bicarbonate, Aluminium hydroxide gel, Aluminium Phosphate, Calcium carbonate, Magnesium carbonate, Magnesium trisilicate, Magnesium oxide, combinations of antacid preparations.

iii) Protective and Adsorbents.  Bismuth subcarbonate and Kaolin.

iv)       Saline cathartics - Sodium Potassium tartrate and Magnesium sulfate. 

Topical Agents-

i)     Protectives -Talc, Zinc Oxide, Calamine, Zinc stearate, Titanium dioxide, Silicone polymers.

ii)    Antimicrobials and Astringents - Hydrogen peroxide, Potassium permanganate, Chlorinated lime, Iodine, Solutions of iodine, Povidone - iodine, Boric acid, Borax, Silver nitrate, Mild silver protein, Mercury, Yellow mercuric oxide, Ammoniated mercury.

iii)   Sulfur and its compounds - Sublimed sulfurs, Precipitated sulfur, Selenium sulfide.

iv)    Astringents:- Alum and Zinc Sulphate.

(E) Dental Products, Sodium fluoride, stannous fluoride, Calcium carbonate, Sodium meta phosphate, Dicalcium phosphate, Strontium chloride, Zinc chloride.

(F)Inhalants - Oxygen, Carbon dioxide, Nitrous oxide.

(G)Respiratory stimulants - Ammonium carbonate.

(H)Expectorants and Emetics - Ammonium chloride*, Potassium iodide, Antimony Potassium tartrate.

(1)Antidotes - Sodium nitrite

2.Major Intra and Extracellular electrolytes-

(A)     Electrolytes used for replacement therapy - Sodium chloride and its preparations, Potassium chloride and its preparations.

(B)     Physiological acid-base balance and electrolytes used- Sodium acetate, Potassium acetate, Sodium bicarbonate injection, Sodium citrate, Potassium citrate, Sodium lactate injection, Ammonium chloride and its injection.

(C)     Combination of oral electrolyte powders and solutions.

3.     Inorganic Official compounds of Iron, Iodine, Calcium Ferrous Sulfate and Calcium gluconate.

4.     Radio pharmaceuticals and Contrast media - Radio activity Alpha, Beta and Gamma Radiations, Biological effects of radiations, Measurement of radio activity G.M. Counter - Radio isotopes - their uses, storage and precautions with special reference to the official preparations.

Radio Opaque Contrast media - Barium sulfate.

5.     Quality control of Drugs and Pharmaceuticals - Importance of quality control, significant errors, methods used for quality control, sources of impurities in Pharmaceuticals. Limit tests for arsenic, chloride, sulfate, iron and heavy metals.

6.Identification tests for cations and anions as per Indian Pharmacopoeia.

 PRACTICAL

(75 hours)

1 .    Identification tests for inorganic compounds particularly drugs and pharmaceuticals.

2.     Limit test for chloride, sulfate, arsenic, iron and heavy metals.

3.     Amy of inorganic Pharmaceuticals involving each of the following methods of

compounds marked with (*) under theory.

a.      Acid-Base titrations (at least 3)

b.Redox titrations (One each of Permanganometry and iodimetry).

C.      Precipitation titrations (at least 2)

d.      Complexometric titrations (Calcium and Magnesium).

Books Recommended.. (latest editions)

1      Indian Pharmacopoeia.

PHARMACOGNOSY

 Theory (75 hours)

1.     Definition, history and scope of Pharmacognosy including indigenous system of

medicine.

2.     Various systems of classification of drugs of natural origin.

3.     Adulteration and drug evaluation, significance of Pharmacopoeial standards.

4.     Brief outline of occurrence, distribution outline of isolation, identification tests,.

therapeutic effects and pharmaceutical applications of alkaloids, terpenoids, glycosides, volatile oils, tannins and resins.

5.     Occurrence, distribution, organoleptic evaluation, chemical constituents including tests wherever applicable and therapeutic efficacy of following categories of drugs

(a)Laxatives: Aloe, Rhubarb, Castor oil, lspaghula, Senna.

(b)     Cardiotonics - Digitalis, Aduna.

(c)     Carminatives &    G.I. regulators - Umbelliferous fruits. Coriander, Fennel, Ajowan, Cardamom, Ginger, Black pepper, Asafoetida, Nutmeg, Cinnamon, Clove.

(d)     Astringents - Catechu.

(e)     Drugs acting on nervous system - Hyoscyamus, Belladonna, Aconite, Ashwagandha, Ephedra, Opium, Cannabis, Nux vomica.

(f)     Antihypertensives - Rauwolfia

(g)Antitussives - Vasaka, Tolu balsam, Tulsi.

(h)Antirheumatics - Guggul, Colchicum.

(i)Antitumour-Vinca.

(j)Antileprotics - Chaulmoogra oil.

(k)Antidiabetics - Pterocarpus, Gymnema sylvestre.

(1)Diuretics - Gokhru, Punarnava.

(m)    Antidysenterics - Ipecacuanha.

(n)     Antiseptics and disinfectants -  Benzoin, Myrrh, Neem,  Curcuma.

o)      Antimalarials - Cinchona.

(p)     Oxytocics - Ergot

(q)Vitamins - Shark liver Oil and Amla

(r)     Enzymes - Papaya, Diastase, Yeast

(r)Perfumes and flavoring agents - Peppermint oil, Lemon oil, orange oil, lemon grass oil,

Sandalwood.

(t)    Pharmaceutical aids - Honey, Arachis Oil, Starch, Kaolin. Pectin, Olive Lanolin, Beeswax,         Acacia, Tragacanth, Sodium alginate, Agar, Guar gurn, Gelatin.

(u)   Miscellaneous - Liquorice, Garlic, Picrorhiza, Dioscorea, Linseed, Shatavari, Shankhupushpi,         Pyrethrum, Tobacco.

6.    Collection and preparation of crude drugs for the market as exemplified by Ergot, Opium,         Rauwolfia, Digitalis, Senna.

7.     Study of source, preparation and identification of fibres used in sutures and surgical dressings         - cotton, silk, wool and regenerated fibres.

8.    Gross anatomical studies of :- Senna, Datura, Cinnamon, Cinchona, Fennel, Clove, Ginger, Nux vomica,  Ipecacuanha.

PRACTICAL (75 hours)

1.     Identification of drugs by morphological characters.

2.     Physical and chemical tests for evaluation of drugs wherever applicable.

3.     Gross anatomical studies (t.s.) of the following drugs Senna, Datura, Cinnamon

        Cinchona, Coriander, Fennel, Clove, Ginger, Nux vomica, lpecacuanha.

4.     Identification of fibres and surgical dressings.

5.     Identification of fibres and surgical dressings.

 

BIOCHEMISTRY AND CLINICAL  PATHOLOGY

 Theory (50 hours)

1.     Introduction to biochemistry.

2.     Brief chemistry and role of proteins, polypeptides and amino acids, classification,

        Qualitative tests, Biological value, Deficiency diseases.

3.   Brief chemistry and role of Carbohydrates, Classification, qualitative tests. Diseases related to carbohydrate metabolism.

4.     Brief chemistry and role of Lipids, Classification, qualitative tests. Diseases related to lipids metabolism.

5.Brief chemistry and role of Vitamins and Coenzymes.

6.     Role of minerals and water in life processes.

7.     Enzymes: Brief concept of enzymatic action, factors affecting it, therapeutic and

pharmaceutical importance.

8.Brief concept of normal and abnormal metabolism of proteins, carbohydrates and lipids.

9.Introduction to pathology of blood and urine.

(a)Lymphocytes and Platelets, their role in health and disease.

(b)    Erythorcytes - Abnormal cells and their significance.

(c)    Abnormal constituents of urine and their significance in diseases.                                  

 PRACTICAL (75 hours)

1.     Detection and identification of Proteins, Amino acids, Carbohydrates and Lipids.

2.Analysis of  normal and abnormal constituents of Blood and Urine (Glucose, Urea, Creatine,

Creatinine, Creatinine, Cholesterol, Alkaline phosphatase, Acid phosphatase, Bilirubin,

SGPT, SGOT, Calcium, Diastase, Lipase).

3 .    Examination of sputum and faeces (microscopic & staining).

4.     Practice in injecting drugs by intramuscular, subcutaneous and intravenous routes.

Withdrawal of blood samples.

HUMAN ANATOMY AND PHYSIOLOGY

Theory (75 hours)

1.Scope of Anatomy and Physiology.

       Definition of various terms used in Anatomy

2.    Structure of cell, function of its components with special reference to mitochondria and

3.     Elementary tissues of the body, i.e. epithelial  tissue, muscular tissue, connective tissue and          nervous tissue.

4.      Structure and function of skeleton. Classification of joints and their function, Joint disorder.

5.     Composition of blood, functions of blood elements. Blood group and coagulation of blood.   Brief information regarding disorders of blood.

6.      Name and functions of lymph glands.

7.     Structure and functions of various parts of the heart. Arterial and venous system with special          reference to the names and positions of main arteries and veins. Blood pressure and its          recording. Brief information about cardiovascular disorders.

8.     Various parts of respiratory system and their functions. Physiology of respiration.

9.   Various parts of urinary systems and their functions, structure and functions of kidney.         Physiology of Urine formation. Pathophysiology of renal diseases and oedema.

10.    Structure of skeletal muscle. Physiology of muscle contraction. Names, positions,                    attachments and functions of various skeletal muscles. Physiology of neuromuscular          junction.

11.  Various parts of central nervous system, brain and its parts, functions and reflex action.          Anatomy and Physiology of autonomic nervous system.

12.   Elementary knowledge of structure and functions of the organs of taste, smell, ear, eye and   skin. Physiology of pain.

13.Digestive system; names of the various parts of digestive system and their functions. Structure and functions of liver, physiology of digestion and absorption.

14.    Endocrine glands and hormones: Location of the glands, their hormones and functions.

         Pituitary, Thyroid, Adrenal and Pancreas.

15. Reproductive System: Physiology and anatomy of Reproductive system.

 PRACTICAL

(50 Hours)

1.Study of human skeleton.

2.Study with the help of charts and Models of the following systems and organs:

(a)Digestive system

(b)Respiratory system

(c)Cardiovascular system

(d)Urinary system

(e)Reproductive system

(f)Nervous system

(g)Eye

(h)Ear

3.Microscopic examination of epithelial tissue, cardiac muscle, smooth muscle, Skeletal muscle, connective tissue and nervous tissue.

4.Examination of blood films for TLC, DLC and malarial parasite.

5.Determination of clotting time of blood, erythrocyte sedimentation rate, and hemoglobin value.

6.Recording of body temperature, pulse, heart rate, blood pressure and ECG. 

HEALTH EDUCATION AND COMMUNITY PHARMACY

Theory (50 hours)

1.            Concept of health - Definition of physical health, mental health, social health, spiritual

health - determinants of health, indicators of health, concept of disease, natural history of diseases, the disease agents, concept of prevention of diseases.

2.            Nutrition and Health  Classification of foods, requirements, diseases induced due to

deficiency of proteins, vitamins and minerals - treatment and prevention.

3.      Demography and family planning - Demography cycle, fertility, family planning, contraceptive methods, behavioral methods, natural family planning method, chemical method, mechanical methods, hormonal contraceptives, population problem of India.

4.      First aid - Emergency treatment in shock, snake-bite, bums, poisoning, heart disease, fractures and resuscitation methods. Elements of minor surgery and dressings.

5.      Environment and health - Sources of water supply, water pollution, purification of water, health and air, noise, light - solid waste disposal and control - medical entomology, arthropod borne diseases and their control, rodents, animals and diseases.

6.      Fundamental principles of microbiology - classification of microbes, isolation, staining                                 techniques of organisms of common diseases.

7.      Communicable diseases - Causative agents, mode of transmission and prevention.

(a)    Respiratory infections - Chicken pox, measles, influenza, diphtheria, whooping cough and tuberculosis.

(b)    Intestinal infections: Poliomyelitis, Hepatitis, Cholera, Typhoid, Food poisoning, Hookworm infection.

(c)    Arthropod borne infections - Plague, Malaria, Filariasis.

(d)    Surface infections - Rabies, Trachoma, Tetanus, Leprosy.

(e)    Sexually transmitted diseases - Syphilis, Gonorrhea, AIDS.

8.      Non-communicable diseases - Causative agents, prevention, care and controls Cancer, Diabetes, Blindness, Cardiovascular diseases.

9.      Epidemiology its scope, methods, uses, dynamics of disease transmission. Immunity and immunisation: Immunoligical products and their dose schedule. Principles of diseases control and prevention, hospital acquired infection, prevention and control. Disinfection, types of disinfection, disinfection procedures, for faeces, urine, sputum, room, linen, dead-bodies, instruments.

  

DIPLOMA  SECOND   YEAR 

PHARMACEUTICS-II

Theory(75 hours)

1.            Dispensing Pharmacy:

i)Prescriptions - Reading and understanding of prescriptions; Latin terms commonly used (Detailed study is not necessary), Modern methods of prescribing, adoption of metric system. Calculations involved in dispensing.

ii)     Incompatibilities in Prescriptions - Study of various types of incompatibilities- physical chemical and therapeutic.

iii)    Posology- Dose and dosage of drugs, Factors influencing dose, Calculations of doses on the basis of age, sex and surface area. Veterinary doses.

2.      Dispensed Medications:

(Note: A detailed study of the following dispensed medication is necessary. Methods of preparation with theoretical and practical aspects, use of appropriate containers and closures. Special labeling requirements and storage conditions should be high-lighted).

i)      Powders - Types of Powders-Advantages and disadvantages of powders, Granules, Cachets and Tablet triturates. Preparation of different types of powders encountered in prescriptions. Weighing methods, possible errors in weighing, minimum weighable amounts and weighing of a material below the minimum weighable amount, geometric dilution and proper usage and care of dispensing balance.

ii)      Liquid Oral Dosage Forms:

(a)    Monophasic - Theoretical aspects including commonly used vehicles, essential adjuvant like stabilizers, colorants and flavors, with examples.

Review of the following monophasic liquids with details of formulation and practical methods.

Liquids for internal administration Liquids for external administration or used on mucous membranes

Mixtures  and concentrates                      Gargles

Syrups  and Elixirs                           Mouth washes, Throat-paints,  Douches

                                                            Ear Drops, Nasal drops & Sprays Liniments Lotions

(b)     Biphasic Liquid Dosage Forms

i)      Suspensions (elementary study)-Suspensions containing diffusible solids and liquids and their preparations. Study of the adjutants used like thickening agents, wetting agents, their necessity and quantity to be incorporated. Suspension of precipitate forming liquids like tinctures, their preparations and stability. Suspensions produced by chemical reaction. An introduction to flocculated/non- flocculated suspension system.

ii)     Emulsions - Types of emulsions, identification of emulsion systems, formulation of emulsions, selection of emulsifying agents, Instabilities in emulsions, Preservation of emulsions.

iii)    Semi-Solid Dosage Forms:

(a)     Ointments - Types of ointments,  classification and     selection of dermatological vehicles., Preparation  and stability of ointments by the following processes:                                               (i) Trituration (ii)Fusion (iii) Chemical reaction (iv) Emulsification.

(b)     Pastes - An introduction to the different types of jellies and their preparation.

 (c)     Jellies - An introduction to the different types of jellies and their preparation.

(d)     An elementary study of poultice.

(e)     Suppositories and pessaries - Their relatives merits and demerits, types of suppositories, suppository bases, classification, properties, Preparation and packing of suppositories. Use of suppositories for drug absorption.

iv)     Dental and Cosmetic Preparations

Introduction to Dentrifices, Facial cosmetics, Deodorants, Antiperspirants, Shampoos, Hair dressings and Hair removers.

v)      Sterile Dosage Forms

(a)     Parenteral dosage forms - Definition, General requirements for parenteral dosage forms. Types of parenteral formulations, vehicles, adjuvants, processing, personnel, facilities and Quality control. Preparation of Intravenous fluids and admixtures-Total parenteral nutrition, Dialysis fluids.

(b)     Sterility testing, Particulate matter monitoring- Faulty seals-packaging.

(c)    Ophthalmic Products - Study of essential characteristics of different ophthalmic preparations. Formulation additives, special precautions in handling and storage of ophthalmic products.

PRACTICAL (100 hours)

Dispensing of at least 100 products covering a wide range of preparations such as mixtures, emulsions, lotions, liniment,N.,T-.. preparations, ointments, suppositories, powders, incompatible prescriptions etc.

Books recommended          (Latest editions)

1.Indian Pharmacopoeia.

2.British Pharmacopoeia.

3.National Formularies (N.F.l., B.N.F.)

4.Remington's Pharmaceutical Sciences.

5 .       Martindale's Extra Pharmacopoeia.

PHARMACEUTICAL CHEMISTRY 11

Theory (100 hours)

1.            Introduction to the nomenclature of organic chemical systems with particular reference to hetero-eyclic system containing upto 3 rings.

2.     The Chemistry of following Pharmaceutical organic compounds, covering their nomenclature, chemical structure, uses and the important Physical and Chemical properties (Chemical structure of only those compounds marked with asterisk(*).

The stability and storage conditions and the different type of Pharmaceutical formulations of these drugs and their popular brand names.

Antiseptics and Disinfectants - Proflavine*, Benzalkonium chloride, Cetrimide, Chloro

 cresol*, Chloroxylene, Formaldehyde solution, Hexachlorophene, Liquified phenol, Nitro Furantoin.

Suifonamides - Sulfadiazine,  Sulfaguanidine*, Phthalyl  sulfathiazole, Succinyl sulphathiazole           Sulfamethoxy pyridazine, Sulphadimethoxine, Sulfa methoxazole, co- trimoxazole, Sulfacetamide*.

Antileprotic Drugs - Clofazimine, Thiambutosine, Dapsone*, Solapsone.

Anti-tubercular Drugs - Isoniazid*, PAS*, Streptomycin, Rifampicin, Ethambutol*, Thiacetazone, Ethionamide, Cycloserine, Pyrazinamide*.

Antiamoebic and Anthelmintic Drugs - Emetine,Metronidazole*, Halogenated hydroxyquinolines, diloxanide furoate, Paromomycin Piperazine*, Mebendazole, D. E. C.

Antibiotics-   Benzyl Penicillin*, Phenoxy methyl Penicillin*, Benzathine Penicillin, Ampicillin*,         Cloxacillin, Carbenicillin, Cephaloridine, Cephalothin, Griseofulvin, Chloramphenicol.

Antifungal agents - Undecylenic acid, Tolnaftate, Nystatin, Amphotericin, Hamycin.

Antimalarial Drugs - Chloroquine*, Amodiaquine, Primaquine, Proguanil, Pyrimethamine*, Quinine, Trimethoprim.

Tranquilizers - Chlorpromazine*, Prochlor Perazine. Trifluperazine, Thiothixene, Haloperidol*, Triperidol, Oxypertine, Chlordizepoxide, Diazepam, Loranpam, Meprobamate.

Hypnotics-Phenebarbitone*, Butobarbitone, Cyclobarbitone, Ni Glutethimide* .'Methyprylon,  paraldehyde, Triclofos-sodium.

General Anaesthtics - Halothane*, Cyclopropane*, Diethyl ether*, Methohexital sodium, Thiopental sodium, Trichloro ethylene.

Antidepressant Drugs - Amitriptyline, Nortriptyline, Imipramine*,  Tranyl cypromine.

Analeptics - Theophylline, Caffeine*, Coramine*, Dextro-amphetamine.

Adrenergic Drugs - Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine, Salbutamol, Terbutaline, Ephedrine*, Ephedrine*, Pseudo-ephedrine.

Adrenergic Antagonist - Tolazoline, Propranolol*, Practalol.

Cholinergic Drugs- Neostigmine*, Pyridostigmint, Pralidoxime, Pilocarpine,  Physiostigmine*.

Cholinergic Antagonists - Atropine*, Hyoscine, Homatropine, Propantheline,  Benztropine, Tropicamide, Biperiden*.

Diuretic Drugs - Furosemide*, Chlorothiazide, Hydrochlorothiazide*, Benzthiazide, Urea*, Mannitol*, Etbacrynic Acid.

Cardiovascular Drugs - Ethyl nitrite*, Glyceryl trinitrate, Alpha methyl dopa, Guanethidine, Clofibrate, Quinidine.

Hypoglycemie Agents - Insulin, Chlorpropamide*, Tolbutamide Glibenclamide, Phenformin*, Metformin.

Coagulants and    Anti- Coagulant - Heparin, Thrombin, Menadione's, Bishydroxycoumarin,             Warfarin sodium.

Local Anaesthetics - Lignocaine*, Procane*, Benzocaine.

Histamine and Anti histaminic Agents - Histamine, Diphenhydramine*, Promethazine, Cyproheptadine, Mepyramine, Pheniramine, Chlorpheniramine*.

Analgesics and Anti-pyreties - Morphine, Pethidine*, Codeine, Methadone, Aspirin*. Paracetamol*, Analgin, Dextropropoxyphene, Pentazocine.

Non-steriodal anti-inflammatory Agents- Indomethacin*, phenylbutazone*, Oxyphenbutazone, lbuprofen.

 Thyroxine and Antithyroids-  Thyroxine*, Methimazole, Methyl thiouracil, Propylthiouracil.

Diagnostic Agents - lopanoic Acid, Propyliodone, Sulfo-bromophtalein, Sodium, Indigotindisulfonate Sodium (Indigo Carmine), Evans blue, Congo Red, Fluorescien  Sodium.

*Anticonvulsants, cardiac glycosides, Antiarrhythmic antihypertensives & vitamins.

Steroidal Drugs - Betamethazone, Cortisone, Hydrocortisone, prednisolone, Progesterone, Testosterone, Oestradiol, Nandrolone.

Anti-Neoplastic Drugs - Actinomycins, Azathioprine, Busulphan, Chlorambucil, Cisplatin cyclophosphamide, Daunorubicin, Hydrochloride, Fluorouracil, Mercaptopurine, Methotrexate, Mitomycin.

PRACTICAL

1.      Systematic qualitative testing of organic drugs involving Solubility determination, melting point and/or boiling point, detection of elements and functional groups (10 compounds).

2.      Official identification tests for certain groups of drugs included in the I.P. like barbiturates, sulfonamides, phenothiazines, Antibiotics etc. (8 compounds).

2.Preparation of three simple organic preparations.

Books Recommended: (Latest editions)

 1 .    Pharmacopoeia of India.

2.     British Pharmaceutical Codex.

3.     Martindale's Extra Pharmacopoeia.

PHARMACOLOGY AND TOXICOLOGY

Theory (75 hours) 

1.Introduction to Pharmacology

2.Routes of administration of drugs, their advantages and disadvantages

3.Various processes of absorption of drugs and the factors affecting them. Metabolism , Distribution and Excretion of drugs.

4.General mechanism of drug action and the factors which modify drug action.

5.Pharmacological classification of drugs. The discussion of drugs should emphasize the following aspects:

I.Drug acting on central nervous system

(a)General Anesthetics, adjunction aneasthesia, Intravenous anaesthesia.

(b)Analgesic antipyretic and non steroidal anti-inflammatory drugs, Narcotic analgesic, Anti rheumatic and antigout remedies. Sedative and Hypnotics. Psycopharmacological agents, Anticonvulsant and analeptics.

(c)Centrally acting muscle relaxants and Antiparkinsonism agents

II.Local Anaesthetics

III.Drugs acting on autonomic nervous system.

(a)Cholinergic drugs, Anticholinergic drugs, Anticholinestrase drugs.

(b)Adrenergic drugs, Adrenergic receptor blockers.

(c)Neurone blockers and ganglion blockers.

(d)Neuromuscular blocker, drug used in Mysthenia gravis.

         IV            Drugs acting on eyes, Mydriatics, drugs used in glaucoma.

         V            Drugs acting on respiratory system-Respiratory stimulant, Bronchodilators, Nasal decongestant, expectorant and antitussive agents.

         VI           Antacids, Physiological role of histamine and serotonin, Histamine and anti histamine, Prostaglandins.

         VII          Cardiovascular drugs, cardiotonic drugs, Antiarrythmic agents, Anti anginal agents, Antihypertensive agents, Peripheral vasodilators, and Drugs used in atherosclerosis.

          VIII        Drugs acting on blood and blood forming organs, Heamatinics, Coagulants and Anticoagulants, Heamostatics, Blood substitute and plasma expanders.

            IX        Drugs affecting renal function- Diuretics and anti diuretics

             X         Hormones and hormone antagonist- Hypoglycemic agents, Antithyroid drugs, sex hormones and oral contraceptives, Corticosteroids.

             XI       Drugs acting on Digestive system- Carminative, Digestant bitters, Antacids and drugs used in peptic ulcers, Purgative and Laxative, Antidiarrhoeal, emetics, Antiemetics, Antispasmodic.

6.Chemotherapy of microbial diseases- Urinary antiseptics, Sulfonamides, Penicillins, Streptomycin, Tetracyclines and other antibiotics.

7.Chemotherapy of protozoal diseases- Anthelmintic drugs

8.Chemotherapy of cancer

9.Disinfectants and antiseptics.

A detailed study of the action of drugs on each organ is not necessary. 

PHARMACOLOGY PRACTICAL

(50 hours) 

The first six of the following experiments will be done by the student while the remaining will be demonstrated by the teacher.

1.Effects of K+ , Ca ++, acetyl choline and adrenaline on Frogs heart.

2.Effect of acetyl choline on rectus abdominus muscle of Frog and Guinea pig ilium.

3.Effect of spasmogens and relaxant on rabbits intestine.

4.Effect of local anaesthetics on rabbit cornea.

5.Effect of Mydriatics and myotics on Rabbits eye,

6.To study the action of strychnine on frog .

7.Effects of digitalis on frog's heart.

8.Effect of hypnotics in mice.

9.Effect of convulsant and anticonvulsant in mice and rats.

10.Test of pyrogens.

11.Taming and hypnosis potentiating effect of chlorpromazine in mice/rats.

12.Effect of diphenhydramine in experimentally produced asthma in guinea pigs.

PHARMACEUTICAL JURISPRUDENCE

Theory (50 hours)

1.   Origin and nature of Pharmaceutical legislation in India, its scope and objectives. Evolution of the 'Concept of Pharmacy' as an integral part of the Health care system.

2.  Principles and significance of Professional Ethics. Critical study of the code of Pharmaceutical Ethics drafted by Pharmacy Council of India.

3.   Pharmacy Act, 1948 - The General study of the Pharmacy Act with special reference to Education Regulations, working of State and Central Councils, constitution of these councils and functions. Registration procedures under the Act.

4.     The Drugs and Cosmetics Act, 1940 - General study of the Drugs and Cosmetics Act and the Rules thereunder. Definitions and salient features related to retail and whole sale distribution of drugs. The powers of Inspectors, the sampling procedures and the procedure and formalities in obtaining licenses under the rule. Facilities to be provided for running a Pharmacy effectively. General study of the schedules with special reference to schedules C,C,F,G,JH,P and X and salient features of labeling and storage conditions of drugs.

5.     The Drugs and Magic Remedies (Objectionable Advertisement) Act, 1954 - General study of Act, Objectives, special reference to he laid on Advertisements, Magic remedies and objectionable and permitted advertisements-diseases which cannot be claimed to be cure.

6.     Narcotic Drugs and Psychotropic Substances Act, 1985-A brief study of the act with special reference to its objectives, offences and punishment.

7.     Brief introduction to the study of the following acts:

1 .     Latest Drugs (Price Control) Order in force.

2.      Poisons Act 1919 (as amended to date)

3.Medicinal and Toilet Preparations (Excise Duties) Act, 1955 (as amended to date)

4.      Medical Termination of Pregnancy Act, 1971 (as amended to date)

Books Recommended: (Latest edition)..

Bare Acts of the said laws published by the Government.

DRUG STORE AND BUSINESS MANAGEMENT

 Theory (75 hours)

Part 1 Commerce (50 hours)

1.     Introduction - Trade, Industry and Commerce, Functions and subdivision of Commerce,

Introduction to Elements of Economics and Management.

2.Forms of Business Organizations.

3.     Channels of Distribution.

4.  Drug House Management - Selection of Site, Space lay-out and legal requirements. Importance and objectives of Purchasing, selection of suppliers, credit information, tenders, contracts and price determination and legal requirements thereto. Codification, handling of drug stores and other hospital supplies.

5.     Inventory Control - objects and importance, modern techniques like ABC, VED analysis,

the lead time, inventory carrying cost, safety stock, minimum and maximum stock levels, economic order quantity, scrap and surplus disposal.

6.     Sales Promotion, Market Research, Salesmanship, qualities of a salesman, Advertising and Window Display.

7.     Recruitment, training, evaluation and compensation of the pharmacist.

8.     Banking and Finance - Service and functions of bank, Finance Planning and sources of finance.

Part 11 Accountancy (25 hours):

1.     Introduction to the accounting concepts and conventions, Double entry, Book keeping, Different kinds of accounts.

2.     Cash Book.

3.     General Ledger and Trial Balance.

4.     Profit and Loss Account and Balance Sheet.

5.     Simple techniques of analysing financial statements.

Introduction to Budgeting

Books Recommended: (Latest editions)

1.Remington Pharmaceutical Sciences.

HOSPITAL CLINICAL PHARMACY

Theory (75 hours)

Part-1: Hospital Pharmacy: 

1.Hospitals- Definition , Function , classification based on various criteria, organisation , management and health delivery system in India.

2.Hospital Pharmacy:

a)Definition

b)Function and objectives of hospital  pharmaceutical services.

c)Location , layout, flow chart of materials and men.

d)Personnel and facilities requirements including equipments based on individual and basic needs.

e)Requirements and abilities required for hospital pharmacist

3.Drug distribution system in hospitals

a)Out-patient services

b)In-patient services-(a) Types of services. (b) Detailed discussion of unit dose system, floor ward stock system, satellite pharmacy services, central sterile services, bed side pharmacy.

4.Manufacturing :

a)Economical considerations, estimation of demand.

b)Sterile manufacture- Large and small volume parenterals, facilities , requirements, layout, production planning, men power requirements.

c)Non-sterile manufacture- Liquid orals, externals, bulk concentrate.

d)Procurement of stores and testing of raw materials.

5.     Nomenclature and uses of surgical instruments and hospital equipments and health accessories.

6.    P.T.C. (Pharmacy Therapeutic Committee), Hospital Formulary System and their organization, functioning, composition.

7.    Drug Information Service and Drug Information Bulletin.

8.    Surgical dressing like cotton, gauze, bandages and adhesive tapes including their Pharmacopoeial tests for quality. Other hospital supply e.g. I.V. sets, B.G. sets, Royal tubes, Catheters, Syringes etc.

9.    Application of computers in maintenance of records, inventory control, medication monitoring, drug information and data storage and retrieval in hospital and retail pharmacy establishments.

Part II: Clinical Pharmacy

1.  Introduction to Clinical Pharmacy Practice - Definition, scope.

2.    Modern dispensing aspects - Pharmacists and Patient counseling and advice for the use

of common drugs, medication history.

3.    Common daily terminology used in the Practice of Medicine.

4.    Disease, manifestations and pathophysiology including salient symptoms to understand

the disease like Tuberculosis, Hepatitis, Rheumatoid Arthritis, Cardio-vascular diseases, Epilepsy, Diabetes, Peptic Ulcer, Hypertension.

5.    Physiological parameters with their significance. 6.    Drug Interactions

(a)    Definition and introduction.

(b)    Mechanism of Drug  interactions

(c)    Drug - drug interaction with reference to analgesics, diuretics, cardiovascular

drugs, Gastro-intestinal agents. Vitamins and Hypoglycemic agents.

(d)    Drug-food interaction.

7.    Adverse Drug Reactions:

(a)    Definition and significance

(b)    Drug - induced diseases and Teratogenicity.

8.    Drugs in clinical toxicity- Introduction , general treatment of poisoning, systematic poisoning, heavy metal poison, Narcotic drugs, barbiturates, organophosphorous poisons.

9.Drug dependents, Drug abuse, Addictive drugs and their treatment, complications.

10.   Bio-availability of drugs, including factors affecting it.

PRACTICAL (50 hours)

1 .   Preparation of transfusion fluids.

2.    Testing of raw materials used in (1)

3.Evaluation of surgical dressings.

4.Sterilization of surgical instruments, glass ware and other hospital supplies.

5.Handling and use of data processing equipments.  

Books Recommended. (Latest editions)

1Remington's Pharmaceutical Sciences.

2.    Martindale's Extra pharmacopoeia.